Healthcare
Healthcare¶
Genome-wide prediction of disease variant effects with a deep protein language model 'A Model that predects bad genetic variants'
Here we implemented a workflow generalizing ESM1b to protein sequences of any length and used it to predict all ~450 million possible missense variant effects across all 42,336 protein isoforms in the human genome.
The Nucleotide Transformer: Building and Evaluating Robust Foundation Models for Human Genomics A quality set of JAX-enabled transformer models for use in downstream uses.
They use 6mer tokenization and embeddings. Non-commercial license.
Github
!!! abstract " Doctor GPT implements advanced LLM prompting for organizing, indexing and discussing PDFs, and does so without using any type of opinionated prompt processing frameworks "“